The Best Hotels in Italy: 28. St. Regis Florence The St. Regis is considered one of Florence’s most treasured structures, and it’s no wonder—the majestic 14th century palazzo was designed by the legendary Renaissance architect Filippo Brunelleschi himself. Each of its 80 guest rooms and 19 suites boast posh Florentine decor; some even offer step-out balconies and views over the River Arno.