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Denis Katz

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For decades, central nervous system disorders have been diagnosed and treated according to clinical syndromes observable collections of symptoms that often concealed multiple underlying biological processes. While this framework enabled progress, it also imposed significant limitations on therapeutic development.

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The prevailing framework centered on serotonin, norepinephrine, and dopamine dysregulation shaped modern psychiatry and enabled the development of therapies that improved millions of lives. Yet despite these advances, major depressive disorder (MDD) remains among the most persistent and relapsing illnesses in medicine.

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